Louis van Gaal's side were paired with the Belgian outfit in Friday's draw, meaning they avoided opponents such as Lazio, Monaco and CSKA Moscow, as they seek to book their place in the group stage of the competition.
United secretary John Alexander was in a positive mood after attending the draw at Uefa's headquarters in Nyon, insisting that everyone at the club believes they can win the Champions League, adding that midfielders Adnan Januzaj and Marouane Fellaini could help to plot a route past their countrymen.
"We're absolutely delighted to be back in the competition. We're back where we want to be," Alexander toldUefa.com.
"Belgian football is right at the very top and we have two Belgian players [Januzaj and Fellaini] in the squad who keep us abreast of what's going on there. We go into any game with confidence.
"We'd like to think we can win the competition."
The last of the Red Devils' three Champions League triumphs came in 2008 when they beat Chelsea on penalties in Moscow, but they missed out on the competition last season after finishing seventh in the 2013-14 Premier League.
United will host Club Brugge at Old Trafford in the first leg of the play-off tie on Tuesday, August 18, with the return fixture at the Jan Breydel Stadium taking place eight days later.
