The Old Lady's new-look strikeforce offered Massimiliano Allegri a glimpse of what he can expect in the post-Carlos Tevez era by finding the net in quick succession midway through the second half of a drab curtain-raiser to the Italian season.
Mandzukic - who was named in Allegri's starting XI - broke the deadlock in the 68th minute with a towering header from Stephan Lichtsteiner's cross, shortly before substitute Dybala lashed Paul Pogba's lay-off into the roof of Federico Marchetti's net from 10 yards.
Ex-Atletico Madrid forward Mandzukic had missed the game's only other genuine chance straight after half-time when Marchetti easily saved his weak shot.
But the Croatian made amends with a superb opener, and Dybala sealed Juve's win four minutes later to give the Serie A champions a boost before they go in search of a fifth-straight Scudetto.
